Dimethylformamide dimethyl acetal → HCID 67260579, compound

HRID 2359062

Reaction equation

HRID 2359062 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:7](=[O:9])[CH3:8])[S:5][CH:6]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH3:12][N:13]([CH3:15])[CH:14]=[CH:8][C:7]([C:4]1[S:5][CH:6]=[C:2]([CH3:1])[CH:3]=1)=[O:9]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 836541-(4-Methyl-2-thienyl)ethan-1-one

Product 1

HCID 67260579HCID 67260579, compoundYield 100%

Procedure

A mixture of 1-(4-methyl-2-thienyl)ethanone (70.8 mmol) and N,N-dimethylformamide dimethyl acetal (105.1 mmol) was refluxed overnight and then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure and dried in vacuo to afford 13.8 g (100% yield) of 3-(dimethylamino)-1-(4-methyl-2-thienyl)prop-2-en-1-one which was used in the next step without further purification.

Workup

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customdried in vacuo

Sources & evidence

ORD record
ord-5059afaa48714899a0071ff605fd7a13
Source dataset
uspto-grants-2014_04
Patent number
US08685974B2

Linked notes

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