Hydrogen chloride-ethyl acetate → (Cyclohexylmethyl)(methyl)amine hydrochloride
Reaction equation
[CH:1]1([CH2:7][N:8](C)[C:9](=O)OC(C)(C)C)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:17].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:17].[CH:1]1([CH2:7][NH:8][CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of tert-butyl N-(cyclohexylmethyl)-N-methylcarbamate (370 mg, 1.6 mmol) in 4.0 mL of ethyl acetate was added 4 M HCl-ethyl acetate (4 mL). After being stirred at room temperature for 1.5 h, the reaction mixture was concentrated in vacuo, and the residue was rinsed with hexane to obtain the title compound (266 mg, 100%).
Workup
- concentrationthe reaction mixture was concentrated in vacuo
- washthe residue was rinsed with hexane
Sources & evidence
- ORD record
- ord-93b77bf83ce045ec8da2cbc16bcb0bb2
- Source dataset
- uspto-grants-2014_04
- Patent number
- US08686024B2
Reaction notes
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