Hydrogen Peroxide → 5-Aminopyridine-2-carboxamide
Reaction equation
[OH:1]O.[OH-].[Na+].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]#[N:13])=[N:10][CH:11]=1>CO>[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([NH2:13])=[O:1])=[N:10][CH:11]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A 18 ml vial was loaded with a mixture of 30% H2O2 (1 ml), 3N NaOH (3 ml) and MeOH (2.5 ml). To this mixture 5-Amino-pyridine-2-carbonitrile (450 mg, 3.78 mmole) was added at room temperature. Reaction mixture was stirred at rt for 45 minutes, TLC showed the starting material to be consumed. The mixture was diluted with water and filtered; the solid was washed with water and dried to give 480 mg product, 92% yield.
Workup
- customReaction mixture
- customto be consumed
- additionThe mixture was diluted with water
- filtrationfiltered
- washthe solid was washed with water
- customdried
Sources & evidence
- ORD record
- ord-14585d26549942dab63cc5daff13439d
- Source dataset
- uspto-grants-2014_04
- Patent number
- US08691816B2
Reaction notes
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