1,2,3-Thiadiazole → 4-Acetylthiomethyl-1,2,3-thiadiazole

Temperature

23 °C

To a solution of 1,2,3-thiadiazol-4-ylmethanol methanesulfonate (0.90 g, 4.6 mmol) in tetrahydrofuran (9 mL) was added an aqueous solution (2 mL) of sodium thiolacetate [prepared from thiolacetic acid (0.38 mL, 5.3 mmol) and sodium bicarbonate (0.445 g, 5.3 mmol)]. The resulting mixture was stirred at 23° C. for 1 h and diluted with ether (75 mL). The organic solution was washed with water (3×3 mL), dried (MgSO4) and concentrated. The crude mixture was purified by chromatography (silica gel column: 1.4×19 cm) with 50% ether in hexane as eluting solvent to give 0.60 g (75%); ir (film)νmax : 1675 (C=O) cm-1 ; 1Hmr (CDCl3)δ: 2.37 (3H, s, CH3), 4.58 (2H, s, CH2), 8.44 (1H, s, H of thiadiazole). Anal. calcd for C5H6N2OS2 : C 34.47, H 3.47, N 16.08, S 36.80; found: C 34.48, H 3.83, N 16.28, S 36.80.

1. washThe organic solution was washed with water (3×3 mL)
2. dry with materialdried (MgSO4)
3. concentrationconcentrated
4. customThe crude mixture was purified by chromatography (silica gel column: 1.4×19 cm) with 50% ether in hexane
5. washas eluting solvent
6. customto give 0.60 g (75%)

ORD record

ord-03be5b10c4fd453ba614c3165e08c8f8

Source dataset

uspto-grants-1987_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04644061