Hydrochloric Acid → Tert-butyl Piperazine-1-carboxylate Hydrochloride

HRID 2365176

Reaction equation

HRID 2365176 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[ClH:14]>ClCCl.CO>[ClH:14].[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 2755973Tert-butyl Piperazine-1-carboxylate Hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl-1-piperazinecarboxylate (15.0 g) in dichloromethane (150 mL) and methanol (150 ml) at 0° C. was added hydrogen chloride (40 mL; 2M solution in diethyl ether). The mixture was stirred at room temperature for 1.5 hours and reduced in vacuo to yield tert-butyl-1-piperazinecarboxylate hydrochloride (17.9 g).

Sources & evidence

ORD record
ord-cbaa2e69289a45d9a478a9adccf6d32e
Source dataset
uspto-grants-2014_04
Patent number
US08697693B2

Linked notes

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