2-Amino-4,6-dimethoxy-1,3,5-triazine → N-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-4-methyl-3-thiophenesulfonamide

HRID 236529

Reaction equation

HRID 236529 reaction equation
[CH3:1][C:2]1[C:3]([S:7]([N:10]=[C:11]=[O:12])(=[O:9])=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:13][C:14]1[N:19]=[C:18]([O:20][CH3:21])[N:17]=[C:16]([O:22][CH3:23])[N:15]=1>O1CCCC1>[CH3:21][O:20][C:18]1[N:17]=[C:16]([O:22][CH3:23])[N:15]=[C:14]([NH:13][C:11]([NH:10][S:7]([C:3]2[C:2]([CH3:1])=[CH:6][S:5][CH:4]=2)(=[O:8])=[O:9])=[O:12])[N:19]=1

Participants

4

Reactant 2

HCID 278402-Amino-4,6-dimethoxy-1,3,5-triazineHCID 132033314-Methyl-3-thiophenesulfonyl isocyanate

Product 1

HCID 13203333N-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-4-methyl-3-thiophenesulfonamideYield 43.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2 g of 4-methyl-3-thiophenesulfonyl isocyanate was added to a suspension of 1.5 g of 2-amino-4,6-dimethoxy-1,3,5-triazine in 20 ml of tetrahydrofuran and the resulting mixture stirred for 16 hours at ambient temperature. The precipitate thus obtained was filtered off and recrystallized to yield 1.5 g of the desired product, m.p. 154°-156°.

Workup

  1. customThe precipitate thus obtained
  2. filtrationwas filtered off
  3. customrecrystallized

Sources & evidence

ORD record
ord-ea7f7df6ae594cd0a9c4241d69a009a9
Source dataset
uspto-grants-1987_02
Patent number
US04645529

Linked notes

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