Reaction equation
[CH3:1][O:2][NH3+:3].[Cl-].[OH-].[K+].[N:7]([CH2:10][C:11](OCC)=[O:12])=[C:8]=[O:9].Cl>O>[CH3:1][O:2][N:3]1[C:11](=[O:12])[CH2:10][NH:7][C:8]1=[O:9]Participants
Procedure
An aqueous solution prepared by dissolving 3.34 g of hydroxylamine methyl ether hydrochloride in 20 ml of water, was cooled with ice. While stirring the solution, an aqueous solution prepared by dissolving 2.24 g of potassium hydroxide in 20 ml of water, was gradually dropwise added thereto. After completion of the dropwise addition, the reaction system was returned to room temperature and the stirring was continued for 1 hour. Then, the reaction mixture was again cooled with ice, and 2.58 g of ethyl isocyanatoacetate was gradually added. The reaction system was returned to room temperature, and the reaction solution was stirred at a temperature of from 40° to 50° C. for further 0.5 hour. Then, the reaction solution was cooled with ice, and 10 ml of 6N hydrochloric acid was added. The mixture was refluxed for 3 hours, and then cooled with ice, whereby crystals precipitated. The crystals were collected by filtration to obtain 1.8 g of 3-methoxy-2,4-dioxoimidazolidine having a melting point of from 98° to 107° C.
Workup
- customAn aqueous solution prepared
- temperaturewas cooled with ice
- customan aqueous solution prepared
- additionwas gradually dropwise added
- additionAfter completion of the dropwise addition
- customwas returned to room temperature
- additionwas gradually added
- customwas returned to room temperature
- stirringthe reaction solution was stirred at a temperature of from 40° to 50° C. for further 0.5 hour
- additionwas added
- temperatureThe mixture was refluxed for 3 hours
- temperaturecooled with ice, whereby crystals
- customprecipitated
- filtrationThe crystals were collected by filtration
Sources & evidence
- ORD record
- ord-93c9995a83544e3dad523c2084b028c0
- Source dataset
- uspto-grants-1987_02
- Patent number
- US04645761
Linked notes
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