Hydrogen Bromide → 1-(4-Hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrobromide
Reaction equation
[BrH:1].[OH:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:13][CH:12]=[CH:11][CH2:10][CH2:9]2)=[CH:5][CH:4]=1>CC(C)=O>[BrH:1].[OH:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:9][CH:10]=[CH:11][CH2:12][CH2:13]2)=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Aqueous hydrobromic acid (48% w/w) was added dropwise, with stirring, to a solution of 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine (4.0 g.) in acetone (50 ml.) until no further precipitate was obtained. The solid was collected by filtration and recrystallised from ethanol to give 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrobromide (Example 18) (2.9 g.), m.p. 187°-190° C.
Workup
- customwas obtained
- filtrationThe solid was collected by filtration
- customrecrystallised from ethanol
Sources & evidence
- ORD record
- ord-03b8b3cfebe4412193a49d5ec1eff538
- Source dataset
- uspto-grants-1987_02
- Patent number
- US04645771
Reaction notes
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