Hydrochloric Acid → HCID 67226852, compound

Reaction equation

[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 5468216(Z)-3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile

Product 1

HCID 67226852HCID 67226852, compoundYield 99%

Procedure

0.1N Hydrochloric acid (8.3 mL) was added to Compound 44 (200 mg) for dissolution, and purified water (5 mL) was added to the solution, followed by stirring at room temperature for 20 minutes. The reaction mixture was lyophilized, to thereby yield the target product (yield: 224 mg, 99%).

Workup

custompurified water (5 mL)
additionwas added to the solution

Sources & evidence

ORD record: ord-092d2958f5f94ff3b76d3d0f43164c33
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08697742B2

Reaction notes

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