Hydrochloric Acid → HCID 67228720, compound
Reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH3:22])=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH3:22])=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]Participants
3
Procedure
0.1N Hydrochloric acid (12.5 mL) was added to Compound 48 (404 mg) for dissolution, and purified water (20 mL) was added to the solution, followed by stirring at room temperature for 20 minutes. The reaction mixture was lyophilized, to thereby yield the target product (yield: 400 mg, 90%).
Workup
- custompurified water (20 mL)
- additionwas added to the solution
Sources & evidence
- ORD record
- ord-e895fcf375904a93bf956ac72a212cb4