Methylamine → HCID 10149078, compound
Reaction equation
[CH3:1][NH2:2].[F:3][C:4]1[CH:5]=[C:6]([CH:12]2[CH2:14][O:13]2)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]>ClCCl>[CH3:1][NH:2][CH2:14][CH:12]([C:6]1[CH:5]=[C:4]([F:3])[C:9]([F:10])=[C:8]([F:11])[CH:7]=1)[OH:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of methylamine (20 mL, 2.0 M in methanol, 40 mmol) was added 2-(3,4,5-trifluorophenyl)oxirane (0.17 g, 0.98 mmol) at room temperature. The reaction mixture was stirred at that temperature for 24 hours. Solvent and excessive methylamine were evaporated, leaving a solid. The solid was dissolved in dichloromethane (5 mL). To the resulting clear solution was added hexanes (15 mL), standing overnight. The solid precipitant was collected by filtration to yield the title compound (0.14 g) as a white solid.
Workup
- customSolvent and excessive methylamine were evaporated
- customleaving a solid
- waitstanding overnight
- filtrationThe solid precipitant was collected by filtration
Sources & evidence
- ORD record
- ord-8fbffc257eda42ab9f5c8744de2362f5
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06852731B2
Reaction notes
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