Potassium thiocyanate → HCID 178469260, compound
Reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH:5]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[C:6](=[N:8]NC(OC)=O)[CH3:7])[CH3:2].[S-:23][C:24]#N.[K+]>Cl>[F:21][C:18]1[CH:17]=[CH:16][C:15]([N:14]2[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:22])=[C:6]([CH3:7])[N:8]=[C:24]2[SH:23])=[CH:20][CH:19]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
To a suspension of methyl 2-(4-ethoxy-3-((4-fluorophenyl)amino)-4-oxobutan-2-ylidene)hydrazinecarboxylate (3.1 g, 10 mmol) (this material was synthesized according to the protocol described in J. Org. Chem. Soc. 1978, 43, 3392) in 4N HCl (100 mL) was added potassium thiocyanate (1.5 g, 15 mmol) and the mixture was heated to 70° C. for 2 hours. After cooling to room temperature, the solid was filtered and dried to afford ethyl 1-(4-fluorophenyl)-2-mercapto-4-methyl-1H-imidazole-5-carboxylate (57).