Triethylamine → alpha-D-Mannopyranose

HRID 2369765

Reaction equation

HRID 2369765 reaction equation
C1(NC2C(=O)C(=O)C=2)C=CC=CC=1.[OH:14][C@H:15]1[O:23][C@H:22]([CH2:24][OH:25])[C@@H:20]([OH:21])[C@H:18]([OH:19])[C@@H:16]1[OH:17].C(N(CC)CC)C>C(O)C.C(O)C.O.O>[OH:14][C@H:15]1[O:23][C@H:22]([CH2:24][OH:25])[C@@H:20]([OH:21])[C@H:18]([OH:19])[C@@H:16]1[OH:17]

Participants

6

Reactant 2

HCID 8471TriethylamineHCID 86678081alpha-Mannose phenylaminocyclobutenedione2×

Product 1

HCID 185698alpha-D-Mannopyranose

Reagents, catalysts & solvents 3

HCID 702EthanolSolvent2×HCID 962WaterSolventHCID 19096565Water ethanolSolvent

Procedure

Nanoparticles DB052 (200 mg) were stirred up by ultrasounds for 30 minutes in ethanol (5 mL). α-mannose phenylaminocyclobutenedione derivatives (71 mg, 1.8 10−4 mol, structure here above) was dissolved in an ethanol/water mixture (10 ml, 3/2). The α-mannose phenylaminocyclobutenedione derivative solution was added dropwisely to the nanoparticle suspension. Triethylamine (500 μL) was added, and the suspension was stirred for 18 hours. After centrifugation, the nanoparticles were dispersed in water and centrifuged (3 cycles), then dispersed in ethanol and centrifugated (two cycles). Functionalized nanoparticles (DB069) were obtained (200 mg).

Sources & evidence

ORD record
ord-d956c0b2d6f44e7aad3939dd97a400b7
Source dataset
uspto-grants-2014_04
Patent number
US08709747B2

Linked notes

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