(3-Aminopropyl)triethoxysilane → alpha-D-Mannopyranose

HRID 2369766

Reaction equation

HRID 2369766 reaction equation
C1(NC2C(=O)C(=O)C=2)C=CC=CC=1.[OH:14][C@H:15]1[O:23][C@H:22]([CH2:24][OH:25])[C@@H:20]([OH:21])[C@H:18]([OH:19])[C@@H:16]1[OH:17].NCCC[Si](OCC)(OCC)OCC>C(O)C.O.C(N(CC)CC)C.CCO>[OH:14][C@H:15]1[O:23][C@H:22]([CH2:24][OH:25])[C@@H:20]([OH:21])[C@H:18]([OH:19])[C@@H:16]1[OH:17]

Participants

6

Reactant 2

HCID 13521(3-Aminopropyl)triethoxysilaneHCID 86678081alpha-Mannose phenylaminocyclobutenedione2×

Product 1

HCID 185698alpha-D-Mannopyranose

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 8471TriethylamineSolventHCID 19096565Water ethanolSolvent

Procedure

α-mannose phenylaminocyclobutenedione (250 mg; 0.37 mmol) was dissolved in a mixture of Ethanol/H2O (3/2) (10 mL) and triethyamine (400 μL) was added dropwise to the solution of APTS (Aminopropyltriethoxysilane) grafted nanoparticles DB060 (250 mg in 10 ml of EtOH). The mixture was stirred during 16 h. The nanoparticles were then centrifugated and washed with water and ethanol and dried under vacuum to afford 232 mg of grafted nanoparticles. The concentration of α-mannose phenylaminocyclobutenedione grafted on the surface of the DB103 nanoaprticle is 0.089 mmol/g.

Workup

  1. washwashed with water and ethanol
  2. customdried under vacuum
  3. customto afford 232 mg of grafted nanoparticles

Sources & evidence

ORD record
ord-b8eeaa78aaa64ca1b8ddeca525e5f66a
Source dataset
uspto-grants-2014_04
Patent number
US08709747B2

Linked notes

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