2-Thiophenecarboxaldehyde → 2-(Dimethylamino)-2-(thiophen-2-yl)acetonitrile
Reaction equation
Cl.[CH3:2][NH:3][CH3:4].[C-:5]#[N:6].[Na+].[S:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH:13]=O>O.CO>[CH3:2][N:3]([CH3:4])[CH:13]([C:9]1[S:8][CH:12]=[CH:11][CH:10]=1)[C:5]#[N:6]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 30 °C
Procedure
A solution of 131.5 g. of dimethylamine hydrochloride in 200 ml of water was stirred and 59 g of sodium cyanide added. A solution of 112 g of 2-thiophenecarboxaldehyde in 100 ml of methanol was added from a dropping funnel while the temperature was kept below 30° C. The mixture was then maintained at 30° C. for 4 hours; it was then poured into 3 1. of water.
Workup
- customwas kept below 30° C
- additionit was then poured into 3 1
Sources & evidence
- ORD record
- ord-3439f2dd7a824451877a12bef8280552
- Source dataset
- uspto-grants-1979_06
- Patent number
- US04159338
Reaction notes
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