1-(3-Chlorophenyl)piperazine → 1-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine

HRID 237024

Reaction equation

HRID 237024 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[Cl:14][C:15]1[CH:16]=[C:17]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[CH:18]=[CH:19][CH:20]=1>C(N(CC)CC)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:24]2[CH2:23][CH2:22][N:21]([C:17]3[CH:18]=[CH:19][CH:20]=[C:15]([Cl:14])[CH:16]=3)[CH2:26][CH2:25]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 74044-Nitrobenzenesulfonyl chloride

Product 1

HCID 10197251-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzenesulfonyl chloride, 1-(m-chlorophenyl)piperazine, and triethylamine are stirred at reflux to give 1-[(p-nitrophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-dd6266a2b2ba43b992466510e0d45622
Source dataset
uspto-grants-1979_06
Patent number
US04159331

Linked notes

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