4-Bromophenacyl bromide → tert-butyl N-[2-(4-bromophenyl)-2-hydroxyethyl]-N-methylcarbamate

HRID 23715

Reaction equation

HRID 23715 reaction equation
[OH:1][CH:2]([C:13]1[CH:18]=[CH:17][C:16](N2CCOCC2)=[CH:15][CH:14]=1)[CH2:3][N:4]([CH3:12])[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[Br:25]CC(C1C=CC(Br)=CC=1)=O>>[Br:25][C:16]1[CH:17]=[CH:18][C:13]([CH:2]([OH:1])[CH2:3][N:4]([CH3:12])[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 22574361tert-Butyl 2-hydroxy-2-(4-morpholin-4-ylphenyl)ethyl(methyl)carbamate

Product 1

HCID 22574334tert-butyl N-[2-(4-bromophenyl)-2-hydroxyethyl]-N-methylcarbamate

Procedure

As described for the preparation of tert-Butyl 2-hydroxy-2-(4-morpholin-4-ylphenyl)ethyl(methyl)carbamate (Preparations 87-88), 2,4′-dibromoacetophenone was converted to the title compound, isolated as a pale yellow solid.

Sources & evidence

ORD record
ord-8e56bd0d17494d0eadb3bf291f1a949e
Source dataset
uspto-grants-2005_02
Patent number
US06852731B2

Linked notes

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