Methyl (R)-(1-hydroxy-3-methylbutan-2-YL)carbamate → (4R)-4-(Propan-2-yl)-1,3-oxazolidin-2-one
Reaction equation
CO[C:3]([NH:5][C@@H:6]([CH2:10][OH:11])[CH:7]([CH3:9])[CH3:8])=[O:4]>C1(C)C=CC=CC=1>[CH3:9][CH:7]([C@@H:6]1[CH2:10][O:11][C:3](=[O:4])[NH:5]1)[CH3:8]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 150 °C
Procedure
27.2 g (168.7 mmol) of the compound from Example V are dissolved in 400 ml of toluene and stirred under reflux in an oil bath at 150° C. while passing in nitrogen.
Sources & evidence
- ORD record
- ord-7518c1e32d2b4d4fadb76a3e57559c1e
- Source dataset
- uspto-grants-1992_03
- Patent number
- US05095006
Reaction notes
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