Water → HCID 12115477, compound

Aluminum lithium hydride (2 g, 52.7 mmol) was suspended in tetrahydrofuran (60 ml), followed by adding dropwise thereto 2-(1,3-dimethylbutyl)-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]aniline (14 g, 40.5 mmol), and the resulting mixture was stirred at reflux temperature for 3 hours. Water was added to the reaction mixture in small portions under ice-cooling, followed by stirring for 10 minutes. Magnesium sulfate was added thereto and then stirred for 10 minutes. The reaction mixture was filtered through Celite and the filtrate was concentrated under reduced pressure to obtain 13 g of the desired compound.

1. additionby adding dropwise
2. temperatureat reflux temperature for 3 hours
3. temperaturecooling
4. stirringstirred for 10 minutes
5. filtrationThe reaction mixture was filtered through Celite
6. concentrationthe filtrate was concentrated under reduced pressure

ORD record

ord-7d948fc099af47f392b2d1d997b3c77a

Source dataset

uspto-grants-2008_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07459477B2