Thiophene → 5-Chloro-1-(2-thienyl)-1-pentanone

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:12]

Participants

Reactant 2

HCID 8030Thiophene

HCID 740895-Chlorovaleryl chloride

Product 1

HCID 49129955-Chloro-1-(2-thienyl)-1-pentanone

Procedure

Using thiophene (1.00 ml) and 5-chlorovaleryl chloride (1.63 ml) according to the same method as that of Reference Example 1, the title compound (2.20 g) was obtained as a pale yellow solid.

Sources & evidence

ORD record: ord-676a465944f7449390867192bf8a612d
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07462628B2

Reaction notes

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