p-Toluenesulfonic acid → Ethyl 5-hydroxypent-2-ynoate

HRID 237848

Reaction equation

HRID 237848 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]#[C:6][CH2:7][CH2:8][O:9]C1CCCCO1)[CH3:2].C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[CH2:1]([O:3][C:4](=[O:16])[C:5]#[C:6][CH2:7][CH2:8][OH:9])[CH3:2]

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 365785Ethyl 5-(tetrahydro-2H-pyran-2-yloxy)-2-pentynoate

Product 1

HCID 15057368Ethyl 5-hydroxypent-2-ynoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 5-(tetrahydro-pyran-2-yloxy)-pent-2-ynoic acid ethyl ester employing p-toluenesulfonic acid in ethanol.

Sources & evidence

ORD record
ord-18fafd85b6f3414689c4ce92953b4a23
Source dataset
uspto-grants-2014_02
Patent number
US08642603B2

Linked notes

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