Terazosin Hydrochloride → Terazosin

HRID 2379401

Reaction equation

HRID 2379401 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28].O.O.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28]

Participants

3

Reactant 1

HCID 63016Terazosin Hydrochloride

Product 1

HCID 5401Terazosin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Terazosin monohydrochloride dihydrate (620 mg, 1.35 mmol) was dissolved in 100 mL of hot absolute ethanol in a 250 mL Erlenmeyer flask fitted with a ground glass joint. The solution was slowly cooled to room temperature and allowed to stand overnight. The resulting white crystalline precipitate was collected by vacuum filtration to yield 100 mg (0.24 mmol, 17.4%) of the anhydrous crystalline polymorph of terazosin of this invention. The material was found by its powder x-ray diffraction pattern to be free of both the prior art anhydrous crystalline modification and the dihydrate form.

Workup

  1. customfitted with a ground glass joint
  2. filtrationThe resulting white crystalline precipitate was collected by vacuum filtration

Sources & evidence

ORD record
ord-d59d9fb764014b84b9b64fb74483d498
Source dataset
uspto-grants-1994_11
Patent number
US05362730

Linked notes

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