1-Phenylpiperazine → alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

HRID 2379693

Reaction equation

HRID 2379693 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]([OH:23])(=[O:22])[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH2:15]>C(O)C>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:13]([OH:23])=[O:22])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 68114Atropic acid

Product 1

HCID 19433570alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Phenylpiperazine and atropic acid in ethanol is heated under reflux for 18h, cooled to room temperature, and evaporated in vacuo. The solid is triturated with acetone to give the title product.

Workup

  1. customevaporated in vacuo
  2. customThe solid is triturated with acetone

Sources & evidence

ORD record
ord-c44b4576b93d468db51b1b96c49107ff
Source dataset
uspto-grants-1994_11
Patent number
US05364849

Linked notes

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