Glycylglycine → Methacryloylglycylglycine

HRID 2380690

Reaction equation

HRID 2380690 reaction equation
[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4].[C:10](Cl)(=[O:14])[C:11]([CH3:13])=[CH2:12]>O>[C:10]([NH:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4])(=[O:14])[C:11]([CH3:13])=[CH2:12]

Participants

4

Reactant 2

HCID 11163GlycylglycineHCID 13528Methacryloyl chloride

Product 1

HCID 10241886MethacryloylglycylglycineYield 75%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Using Example 1, glycylglycine was reacted with methacryloyl chloride in water at -10° C. After adjustment to a pH of 3, the white slurry was washed with ethanol to remove sodium chloride and water. The product was dried at 80° C. to obtain a good yield (>75%) product with a melting point of 200°-201° C.

Workup

  1. washAfter adjustment to a pH of 3, the white slurry was washed with ethanol
  2. customto remove sodium chloride and water
  3. customThe product was dried at 80° C.
  4. customto obtain

Sources & evidence

ORD record
ord-86af07b8d12f4df8a95f65f97388eba5
Source dataset
uspto-grants-1994_11
Patent number
US05369142

Linked notes

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