Hydrochloric Acid → HCID 67059980, compound
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([F:21])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[F:21][C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-Fluoro-4-(2-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (0.4 g, 1.35 mmol) was dissolved in a solution of hydrogen chloride in dioxane (4 M, 3 mL) and the mixture stirred for 1 hour. The solvent was evaporated under vacuum, and the resulting solid triturated from diethyl ether to give the title compound as a pale yellow solid (0.26 g) which was used without further purification.
Workup
- customThe solvent was evaporated under vacuum
- customthe resulting solid triturated from diethyl ether
Sources & evidence
- ORD record
- ord-c45626e50d4b41efb9e5d766192eaea1
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08642621B2
Reaction notes
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