4-(2-Methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester → Tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Lithium aluminium hydride (0.026 g, 0.7 mmol) was suspended in dry THF (1 mL) under a nitrogen atmosphere and cooled in an ice bath. A solution of 4-(2-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (0.27 g, 0.7 mmol) in dry THF (2 mL) was added drop wise and the reaction mixture stirred for 1 hour. The reaction mixture was diluted with diethyl ether (5 mL) and quenched with hydrochloric acid (1 N, 5 mL). The organic solution was separated and washed with saturated aqueous sodium hydrogen carbonate (5 mL) and brine (5 mL), dried over magnesium sulphate, filtered and the solvent removed under vacuum to give the title compound as a colourless gum (0.13 g). LCMS m/z 292.0 [M+H]+. R.T.=4.57 min (Analytical Method 4).

1. temperaturecooled in an ice bath
2. customquenched with hydrochloric acid (1 N, 5 mL)
3. customThe organic solution was separated
4. washwashed with saturated aqueous sodium hydrogen carbonate (5 mL) and brine (5 mL)
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. customthe solvent removed under vacuum

ORD record

ord-50c532e69923486da2c92a5aafb588e6

Source dataset

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08642621B2