Triethylamine → HCID 86684866, compound

HRID 238363

Reaction equation

HRID 238363 reaction equation
C(N(CC)CC)C.[CH3:8][N:9]1[C:13]([NH2:14])=[CH:12][CH:11]=[N:10]1.[CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[C:17]2[C:25]([O:27][C:28](=O)[C:16]=12)=[O:26]>C1(C)C=CC=CC=1>[CH3:8][N:9]1[C:13]([N:14]2[C:28](=[O:27])[C:16]3[CH:15]=[C:24]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]4=[CH:18][C:17]=3[C:25]2=[O:26])=[CH:12][CH:11]=[N:10]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 69743Naphtho(2,3-c)furan-1,3-dioneHCID 1369272-Methyl-2H-pyrazol-3-ylamine

Product 1

HCID 86684866HCID 86684866, compoundYield 87.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Triethylamine (1.10 mL) was added to a toluene (14 mL) suspension that contained 1-methyl-1H-pyrazol-5-amine (400 mg) and 2,3-naphthalenedicarboxylic anhydride (816 mg), and the obtained solution was then heated to reflux for 2 hours. Thereafter, the reaction solution was cooled to a room temperature, and the precipitated solid was then collected by filtration. The collected solid was washed with ethyl acetate, so as to obtain the title compound (1.00 g) in the form of a colorless solid.

Workup

  1. temperaturethe obtained solution was then heated
  2. temperatureto reflux for 2 hours
  3. filtrationthe precipitated solid was then collected by filtration
  4. washThe collected solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-788b2b43ce4b47b5a5a35bfe3df41dd7
Source dataset
uspto-grants-2014_02
Patent number
US08642626B2

Linked notes

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