5-Chlorosalicylic Acid → 5-chloro-N-(2-chloropyridin-4-yl)-2-hydroxybenzamide

Reaction equation

[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([Cl:19])[CH:14]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([Cl:19])[CH:14]=1)=[O:9]

Participants

Reactant 2

HCID 94475-Chlorosalicylic Acid

HCID 844322-Chloropyridin-4-amine

Product 1

HCID 178602855-chloro-N-(2-chloropyridin-4-yl)-2-hydroxybenzamideYield 12.2%

Procedure

Using 5-chlorosalicylic acid and 4-amino-2-chloropyridine as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record: ord-3ea49b7a61014a8cbcd52a6c44328d62
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263657B2

Reaction notes

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