Dichloromethane → 4-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride

HRID 2389270

Reaction equation

HRID 2389270 reaction equation
[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[CH:7]=1)#[N:2].C(Cl)[Cl:26]>CCOC(C)=O>[Cl-:26].[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][NH2+:15][CH2:14][CH2:13]3)=[CH:8][C:6]=2[CH:7]=1)#[N:2]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67154775Tert-butyl 4-(2-cyano-1-benzofuran-5-yl)piperazine-1-carboxylate

Product 1

HCID 671549194-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The above piperazine (85.3 mg, 0.261 mmol) was dissolved in 5 mL of DCM and 5 mL of EtOAc, and cooled to 0° C. Hydrogen chloride gas was bubbled through the mixture for 30 seconds. The reaction stirred for 30 minutes, warming to ambient temperature. The slurry was concentrated to afford 4-(2-cyano-1-benzofuran-5-yl)piperazin-1-ium chloride.

Workup

  1. customHydrogen chloride gas was bubbled through the mixture for 30 seconds
  2. concentrationThe slurry was concentrated

Sources & evidence

ORD record
ord-c928fe962c8f4c38b5c9417102e38a94
Source dataset
uspto-grants-2012_09
Patent number
US08273737B2

Linked notes

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