Indole-4-carboxaldehyde → 1-[2-(Thien-2-yl)ethyl]indole-4-carbaldehyde

HRID 2394415

Reaction equation

HRID 2394415 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1.CS(O[CH2:17][CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)(=O)=O>>[S:20]1[CH:21]=[CH:22][CH:23]=[C:19]1[CH2:18][CH2:17][N:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 30477232-(2-Thienyl)ethyl methanesulphonate

Product 1

HCID 189734491-[2-(Thien-2-yl)ethyl]indole-4-carbaldehydeYield 39.1%

Procedure

The same procedures used in Example 1 were repeated except for using 435 mg of indole-4-carbaldehyde and 680 mg of 2-(thien-2-yl)ethyl methanesulfonate instead of the benzyl bromide used in Example 1 to give 299 mg of 1-[2-(thien-2-yl)ethyl]indole-4-carbaldehyde as an orange-colored oily substance. The yield thereof was found to be 39%.

Sources & evidence

ORD record
ord-4573cf993a3f4246baa35f49df38e063
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Linked notes

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