Hydrochloric Acid → 3-Amino-4-phenyl-2-butanone hydrochloride (1:1)
Reaction equation
C([NH:4][CH:5]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6](=[O:8])[CH3:7])(=O)C.[ClH:16]>C(O)C>[ClH:16].[NH2:4][CH:5]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6](=[O:8])[CH3:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 3-acetylamino-4-phenyl-2-butanone (12.5 g), 6N HCl (50 ml) and ethanol (50 ml) was stirred under refluxing conditions for 18 hours. The reaction mixture was concentrated under reduced pressure to yield 3-amino-4-phenyl-2-butanone hydrochloride (9.8 g, 81%).
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-c78edbd5751a4a8eba828c8a9ca9e654
- Source dataset
- uspto-grants-1996_02
- Patent number
- US05489602
Reaction notes
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