Hydrazine hydrate (1:1) → HCID 54417124, compound
Reaction equation
[CH2:1]([C:3](=[CH:18][CH:19]([CH3:21])[CH3:20])[CH:4]=[CH:5][CH2:6][N:7]1C(=O)C2=CC=CC=C2C1=O)[CH3:2].O.NN>C(O)C>[CH2:1]([C:3](=[CH:18][CH:19]([CH3:20])[CH3:21])[CH:4]=[CH:5][CH2:6][NH2:7])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-(4-ethyl-6-methyl-2,4-heptadiene-1-yl)phthalimide (17.62 g), hydrazine monohydrate (9.9 g), and ethanol (700 ml) was refluxed for 90 minutes under nitrogen atmosphere. The reaction mixture was evaporated in vacuo. The residue was dissolved in 10% aqueous potassium carbonate solution and extracted with ethyl acetate. The organic extract was washed with brine, dried over anhydrous magnesium sulfate, and evaporated to give 4-ethyl-6-methyl-2,4-heptadiene-1-ylamine as an oil.
Workup
- temperaturewas refluxed for 90 minutes under nitrogen atmosphere
- customThe reaction mixture was evaporated in vacuo
- dissolutionThe residue was dissolved in 10% aqueous potassium carbonate solution
- extractionextracted with ethyl acetate
- extractionThe organic extract
- washwas washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated
Sources & evidence
- ORD record
- ord-20db761e03f74cfb808683b698074923
- Source dataset
- uspto-grants-1996_02
- Patent number
- US05495023
Reaction notes
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