Benzenesulfonyl fluoride, p-chloro- → (2S,4S)-1-Tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate

HRID 2397139Notes

Reaction equation

HRID 2397139 reaction equation
COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C.O=S(=O)(F)c1ccc(Cl)cc1>C1CCOC1.CN1CCCN2CCCN=C12>COC(=O)[C@@H]1C[C@H](F)CN1C(=O)OC(C)(C)C

Participants

5

Reactant 2

HCID 94992Benzenesulfonyl fluoride, p-chloro-HCID 10752873N-Boc-cis-4-hydroxy-L-proline methyl ester

Product 1

HCID 10977773(2S,4S)-1-Tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylateYield 30%

Reagents, catalysts & solvents 2

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 8028TetrahydrofuranSolvent2×

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-25ed82b5525748e980d1747e51460d6d
Source dataset
Deoxyfluorination screen
Original link
View source

Reaction notes

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