Hydrochloric Acid → Megazol
Reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]([NH:12][NH:13][C:14]([NH2:16])=[S:15])=N.Cl>O>[NH2:16][C:14]1[S:15][C:10]([C:3]2[N:2]([CH3:1])[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=2)=[N:12][N:13]=1Participants
4
Reagents, catalysts & solvents 1
Procedure
1-(1-Methyl-5-nitro-2-imidazolecarboximidoyl)-3-thiosemicarbazide (0.3 g.) is heated with 7 ml. of 6N hydrochloric acid for 15 minutes. The resulting solution is cooled and diluted with water. The solid is filtered, washed with water and dried affording 2-(2-amino-1,3,4-thiadiazol-5-yl)-1-methyl-5-nitroimidazole, melting point 266°-8°.
Workup
- temperatureThe resulting solution is cooled
- filtrationThe solid is filtered
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-943998c6fe5a492cb024cfdca4a89a42
- Source dataset
- uspto-grants-1977_05
- Patent number
- US04026903
Reaction notes
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