Methylamine → HCID 19382193, compound

Reaction equation

[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]2)[CH2:2]1.[CH3:14][NH2:15]>>[OH:1][C:3]1([CH2:2][NH:15][CH3:14])[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]1

Participants

Reactant 2

HCID 6329Methylamine

HCID 13672926Ethyl 1-oxa-6-azaspiro[2,5]octane-6-carboxylate

Product 1

HCID 19382193HCID 19382193, compound

Procedure

5.2 g (28 mmol) of ethyl 6-aza-1-oxaspiro[2,5]-octane-6-carboxylate are added dropwise to 30 ml of methylamine solution (25% in water) and the mixture is stirred overnight at room temperature. It is then concentrated and recrystallized from petroleum ether (hygroscopic crystals).

Workup

concentrationIt is then concentrated
customrecrystallized from petroleum ether (hygroscopic crystals)

Sources & evidence

ORD record: ord-fac9ac652b8749cf9bf84992d7ccf1be
Source dataset: uspto-grants-1995_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05453422

Reaction notes

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