Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

Reaction equation

[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19382159HCID 19382159, compound

Product 1

HCID 193822164-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

Procedure

4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

Workup

concentrationThe product is concentrated
customthe crystals are triturated with acetone
filtrationfiltered off with suction
dry with materialdried in a vacuum desiccator over P4O10

Sources & evidence

ORD record: ord-706161d1ccac428bbbe9cfaae2ef2e21
Source dataset: uspto-grants-1995_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05453422

Reaction notes

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