Ethanol, 2,2,2-trifluoro-, sodium salt (1:1) → 5-bromo-6-methoxy-2-(1H-pyrazol-1-yl)pyrimidin-4-amine

HRID 2401167Notes

Reaction equation

HRID 2401167 reaction equation
[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1Cl.FC(F)(F)[CH2:17][O-:18].[Na+]>FC(F)(F)CO>[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1[O:18][CH3:17]

Participants

4

Reactant 2

HCID 23677971Ethanol, 2,2,2-trifluoro-, sodium salt (1:1)HCID 866770175-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-amine

Product 1

HCID 574072385-bromo-6-methoxy-2-(1H-pyrazol-1-yl)pyrimidin-4-amine

Reagents, catalysts & solvents 1

HCID 64092,2,2-TrifluoroethanolSolvent

Procedure

The following example was synthesized using the procedure described for Example 43 from Intermediate 5 using a solution of sodium 2,2,2-trifluoroethanolate in 2,2,2-trifluoroethanol:

Sources & evidence

ORD record
ord-d8b3561c34794839b93bbd67d0e0df76
Source dataset
uspto-grants-2014_08
Patent number
US08796284B2

Reaction notes

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