Hydrochloric Acid → Methyl 2-amino-4,4,4-trifluorobutanoate hydrochloride

Reaction equation

[ClH:1].[NH2:2][CH:3]([CH2:7][C:8]([F:11])([F:10])[F:9])[C:4]([OH:6])=[O:5].Cl.[CH3:13]O>>[ClH:1].[NH2:2][CH:3]([CH2:7][C:8]([F:11])([F:10])[F:9])[C:4]([O:6][CH3:13])=[O:5]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 27565662-Amino-4,4,4-trifluorobutanoic acid hydrochloride

Product 1

HCID 44717559Methyl 2-amino-4,4,4-trifluorobutanoate hydrochloride

Procedure

1.186 g (6.127 mmol) of 2-amino-4,4,4-trifluorobutanoic acid hydrochloride (1:1) were initially charged in 11.6 ml of methanol which had been saturated with hydrogen chloride, and the mixture was stirred under reflux for 4 h. The reaction solution was concentrated and dried under high vacuum. This gave 1.275 g of the target compound (100% of theory).