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Hydrochloric Acid → N-{2-Amino-2-[3-(trifluoromethyl)phenyl]ethyl}formamide hydrochloride

HRID 2402772
Notes
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Reaction equation

HRID 2402772 reaction equation
[CH:1]([NH:3][CH2:4][CH:5]([NH:16]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)=[O:2].[ClH:24]>ClCCl.O1CCOCC1>[ClH:24].[NH2:16][CH:5]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:7]=1)[CH2:4][NH:3][CH:1]=[O:2]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59536815tert-Butyl {2-(formylamino)-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Product 1

HCID 86646631N-{2-Amino-2-[3-(trifluoromethyl)phenyl]ethyl}formamide hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Of the compound from Example 23A, 66 mg (0.2 mmol) were introduced in 1.5 ml of dichloromethane and admixed at RT with 1.56 ml of a 4N solution of hydrogen chloride in dioxane. The reaction mixture was stirred at RT for 1 h. The reaction mixture was freed from the volatile components on a rotary evaporator and dried in an HV. This gave 50 mg (94% of theory) of the title compound.

Workup

  1. customThe reaction mixture was freed from the volatile components on a rotary evaporator
  2. customdried in an HV

Sources & evidence

ORD record
ord-5a2aa4d682614b718ce6cc6e502222d3
Source dataset
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08796324B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes