Hydrochloric Acid → (8aS)-7-(3-fluorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one hydrochloride
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][CH:6]1[C:21](=[O:22])[N:9]2[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][C@@H:8]2[CH2:7]1.[ClH:26]>O1CCOCC1>[ClH:26].[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][CH:6]1[C:21](=[O:22])[N:9]2[CH2:10][CH2:11][NH:12][CH2:13][C@@H:8]2[CH2:7]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of the product from Example 213A (72 mg, 0.207 mmol) in 1,4-dioxane (1 mL) was added a 4 M solution of hydrogen chloride in 1,4-dioxane (1 mL, 4.0 mmol). The resulting mixture was stirred at room temperature for 90 minutes and concentrated and dried in vacuo to give the title compound (59 mg, quantitative).