(-)-3-Hydroxytetrahydrofuran → 3-Nitro-2-[(R)-(tetrahydro-furan-3-yl)-oxy]-pyridine

HRID 240608

Reaction equation

HRID 240608 reaction equation
F[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[O:11]1[CH2:15][CH2:14][C@@H:13]([OH:16])[CH2:12]1>>[N+:8]([C:7]1[C:2]([O:16][C@@H:13]2[CH2:14][CH2:15][O:11][CH2:12]2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 641512(-)-3-HydroxytetrahydrofuranHCID 27628172-Fluoro-3-nitropyridine

Product 1

HCID 584130443-Nitro-2-[(R)-(tetrahydro-furan-3-yl)-oxy]-pyridine

Procedure

Prepared analogously to I.1 from 2-fluor-3-nitropyridine and (R)-tetrahydro-furan-3-ol.

Sources & evidence

ORD record
ord-7219a3f5afee41298ca68aed3657045d
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Linked notes

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