Chlorotrimethylsilane → {(S)-6-[(R)-5-cyano-4-(2,6-dimethyl-benzyl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Reaction equation

[Li+].[Cl-].BrCCBr.C[Si](Cl)(C)C.[CH3:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:14]=1[CH2:15]Br.[CH3:22][O:23][C:24](=[O:48])[CH2:25][C@H:26]1[C:30]2[CH:31]=[CH:32][C:33]([O:35][C@H:36]3[C:44]4[C:39](=[C:40](Br)[C:41]([C:45]#[N:46])=[CH:42][CH:43]=4)[CH2:38][CH2:37]3)=[CH:34][C:29]=2[O:28][CH2:27]1.[NH4+].[Cl-]>O1CCCC1.C(C1C=CC=C(C(C)C)C=1N1C=CN(C2C(C(C)C)=CC=CC=2C(C)C)C1=[Pd-3](Cl)(Cl)C1C(Cl)=CC=CN=1)(C)C.[Zn]>[CH3:22][O:23][C:24](=[O:48])[CH2:25][C@H:26]1[C:30]2[CH:31]=[CH:32][C:33]([O:35][C@H:36]3[C:44]4[C:39](=[C:40]([CH2:15][C:14]5[C:17]([CH3:21])=[CH:18][CH:19]=[CH:20][C:13]=5[CH3:12])[C:41]([C:45]#[N:46])=[CH:42][CH:43]=4)[CH2:38][CH2:37]3)=[CH:34][C:29]=2[O:28][CH2:27]1