3-Acetylpyridine → 3-PYRIDINEACETALDEHYDE, ALPHA-OXO-

Reaction equation

[Se](=O)=[O:2].[C:4]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)(=[O:6])[CH3:5]>>[N:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:4]([CH:5]=[O:2])=[O:6])[CH:8]=1

Participants

Reactant 2

HCID 95893-Acetylpyridine

HCID 24007Selenium Dioxide

Product 1

HCID 102360083-PYRIDINEACETALDEHYDE, ALPHA-OXO-Yield 90.3%

Procedure

3-Pyridylglyoxal (5.0 g, crude) was prepared from selenium dioxide (6.82 g, 61.4 mmol) and 3-acetyl pyridine (5.0 g, 41.0 mmol) according to the typical procedure used for Preparation 1.

Workup

customused for Preparation 1

Sources & evidence

ORD record: ord-5a9319c65e374ddaa6e6fbac48c3e394
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809525B2

Reaction notes

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