N-methyl-N-phenyl-hydrazine → 5-cyclopentyl-N'-methyl-N'-phenyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

HRID 240708

Reaction equation

HRID 240708 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([OH:20])=O)[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:21][N:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH2:23]>>[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([NH:23][N:22]([CH3:21])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:20])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 36299N-methyl-N-phenyl-hydrazineHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 712940585-cyclopentyl-N'-methyl-N'-phenyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 14c) and 1-methyl-1-phenyl-hydrazine (CAN 618-40-6) as starting materials; LC-MS (UV peak area/ESI) 98.0%, 394.1737 (M+H)+.

Sources & evidence

ORD record
ord-196e0bc19b5941eb8d3a2be5fcd72ade
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Linked notes

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