(S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine → HCID 71294248, compound

HRID 240734Notes

Reaction equation

HRID 240734 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=[C:8]([CH:12]=2)[C:9]([OH:11])=O)[CH2:3][CH2:2]1.[CH3:19][O:20][CH2:21][C@@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1[NH2:27]>>[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=[C:8]([CH:12]=2)[C:9]([NH:27][N:23]2[CH2:24][CH2:25][CH2:26][C@H:22]2[CH2:21][O:20][CH3:19])=[O:11])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 7156993(S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidineHCID 712941085-Cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 71294248HCID 71294248, compound

Procedure

The title compound was synthesized in analogy to the procedure described in Example 34 c), using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (example 34b) and (S)-2-methoxymethyl-pyrrolidin-1-yl amine as starting materials (CAN 59983-39-0); MS (ESI) 396.4 (M+Na)+.

Sources & evidence

ORD record
ord-03a7e569ac514ba3a389c6a55fe42f36
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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