Isopropanol → HCID 58504016, compound

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6](Cl)[N:5]=[C:4]([C:11]([NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[S:26][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[F:33])=[N:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:12])[CH:3]=1.[CH:34]([OH:37])([CH3:36])[CH3:35]>>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:37][CH:34]([CH3:36])[CH3:35])[N:5]=[C:4]([C:11]([NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[S:26][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[F:33])=[N:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:12])[CH:3]=1

Participants

Reactant 2

HCID 3776Isopropanol

HCID 58503938HCID 58503938, compound

Product 1

HCID 58504016HCID 58504016, compound

Procedure

According to the same procedure described in Example 204, using the compound prepared in Example 393 instead of the compound prepared in Example 215 and isopropanol instead of 1-cyclopropylethanol, the title compound having the following physical data was obtained.

Sources & evidence

ORD record: ord-d629a47f602c43b78ccc74f94ed30afa
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809538B2

Reaction notes

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