Potassium Carbonate → 8-Cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

HRID 24099

Reaction equation

HRID 24099 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([C:18]#[C:19][Si](C)(C)C)[CH:7]=[C:8]3[C:13]=2[O:12][C:11]([CH3:15])([CH3:14])[CH2:10][C:9]3([CH3:17])[CH3:16])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]1([C:4]2[CH:5]=[C:6]([C:18]#[CH:19])[CH:7]=[C:8]3[C:13]=2[O:12][C:11]([CH3:14])([CH3:15])[CH2:10][C:9]3([CH3:17])[CH3:16])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 187197898-Cyclopropyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman2×

Product 1

HCID 225690068-Cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following general procedure E and using 8-cyclopropyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Intermediate 33, 0.17 g, 0.68 mmol), methanol and potassium carbonate (0.2 g, 1.47 mmol) the title compound was obtained as an oil (0.064 g, 47%).

Sources & evidence

ORD record
ord-931d8dd58b1e4edd80381b11ce10f3fb
Source dataset
uspto-grants-2005_02
Patent number
US06855512B2

Linked notes

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