Cyclopropylboronic acid → HCID 58484562, compound
Reaction equation
Br[C:2]1[CH:3]=[C:4]([CH3:24])[C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([C:16]3[CH:17]=[N:18][C:19]([F:23])=[CH:20][C:21]=3[CH3:22])=[O:15])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH:25]1(B(O)O)[CH2:27][CH2:26]1>>[CH:25]1([C:2]2[CH:3]=[C:4]([CH3:24])[C:5]([N:8]3[CH2:13][CH2:12][N:11]([C:14]([C:16]4[CH:17]=[N:18][C:19]([F:23])=[CH:20][C:21]=4[CH3:22])=[O:15])[CH2:10][CH2:9]3)=[N:6][CH:7]=2)[CH2:27][CH2:26]1Participants
3
Procedure
Using [4-(5-bromo-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (2.2 g) described in Preparation Example 139 and cyclopropylboronic acid (721 mg) and by the reaction and treatment in the same manner as in Preparation Example 100, the title compound (2.39 g) was obtained.
Sources & evidence
- ORD record
- ord-c132e2d5606f40c3817570d7c280ad56
- Source dataset
- uspto-grants-2014_08