Triethylamine → HCID 178512637, compound

Reaction equation

Cl.Cl.[NH:3]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][S:13][CH2:14][CH2:15][NH2:16])[N:11]=1)[C:4]([NH2:6])=[NH:5].[NH:17]([C:21]1[S:22][CH:23]=[C:24]([CH2:26][CH2:27][CH2:28][CH2:29][NH:30][C:31]2[C:34](=O)[C:33](=[O:36])[C:32]=2[O:37]C)[N:25]=1)[C:18]([NH2:20])=[NH:19].C(N(CC)CC)C>CO>[NH:3]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][S:13][CH2:14][CH2:15][NH:16][C:34]2[C:33](=[O:36])[C:32](=[O:37])[C:31]=2[NH:30][CH2:29][CH2:28][CH2:27][CH2:26][C:24]2[N:25]=[C:21]([NH:17][C:18]([NH2:20])=[NH:19])[S:22][CH:23]=2)[N:11]=1)[C:4]([NH2:6])=[NH:5]

Participants

Procedure

A mixture of 2-guanidino-4-[(2-aminoethyl)thiomethyl]thiazole dihydrochloride (0.024 g), 1-[4-(2-guanidinothiazol-4-yl)butylamino]-2-methoxycyclobutene-3,4-dione (0.032 g) and triethylamine (0.03 ml) in dry methanol (1 ml) was stirred for 18 hours at room temperature. The white solid was filtered off, washed with methanol and dried in vacuo to give 1-[2-(2-guanidinothiazol-4-ylmethylthio)ethylamino]-2-[4-(2-guanidinothiazol-4-yl)butylamino]cyclobuten-3,4-dione, (0.022 g), m.p. 208°-210°.