2-(Propan-2-yl)-1,4,5,6-tetrahydropyrimidine → 2-(Propan-2-yl)pyrimidine
Reaction equation
[CH:1]([C:4]1[NH:5][CH2:6][CH2:7][CH2:8][N:9]=1)([CH3:3])[CH3:2].[H][H].[H][H].N#N>N1C=CC=CC=1.[Pt]>[CH:1]([C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2]Participants
6
Procedure
A solution of 70 g of 2-isopropyl-1, 4, 5, 6-tetrahydropyrimidine in 100 ml of pyridine was fed at about 1 ml/min to a column 1"×20" containing about 50 g of 0.5 percent platinum on α-alumina at 300° to 325° C. while sweeping out the column with a mixture of nitrogen and hydrogen. The catalyst had been activated by passing a 2:1 H2 /N2 stream over the bed for two hours. The effluent was distilled giving 2-isopropylpyrimidine at 152° to 155° C. The yield was 73 percent.
Workup
- customfor two hours
- distillationThe effluent was distilled
Sources & evidence
- ORD record
- ord-142d7d6a82464681b8f988d39d9d874b
- Source dataset
- uspto-grants-1985_01
- Patent number
- US04493929
Reaction notes
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